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Question: Which noncoding RNA coats the inactive X-chromosome in regions of heterochromatin?

Options:

  1. Xist RNA
  2. tRNA
  3. HP-1 RNA
  4. 5S rRNA

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1. Xist RNA

Xist RNA is noncoding RNA coats the inactive X-chromosome in regions of heterochromatin.


Explanation:

Xist RNA was subsequently found to physically coat the inactive-X chromosome, and studies in mice demonstrated that Xist remains associated with the inactive-X during mitosis.

The presence of Xist on the mitotic inactive-X supports its role as the transmitter of the epigenetic state of the inactive-X from one cell division cycle to the next. In human cells, however, Xist RNA appears to dissociate from the X-chromosome during mitosis.

Source: ncbi.nlm.nih.gov

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